Donald P. Lesslie, III, D.O.
Associate Professor of Surgery
July 2009 – present
Assistant Professor, Department of Surgery
University of Texas Health Science Center at Houston
Birth Date and Place:
December 30, 1971
Abilene, Texas
Citizenship:
USA
Licensure/Boards:
Texas State Board of Medical Examiners – L7008 (exp. 2/2010)
Commonwealth of Pennsylvania – OS014080 (exp. 10/2008)
American Board of Surgery – Baltimore 9/2007 (exp. 1/2018)
Education:
1990-1994
Abilene Christian University
Abilene, Texas
B.S.-Biology
University of North Texas Health Science Center
Fort Worth, Texas
D.O.
Postgraduate Training:
1999-2000
Rotating Internship
Doctor’s Hospital
Columbus, Ohio
2000-2003
General Surgery Internship and Residency
University of Texas- Houston
Houston, Texas
2003-2005
NIH T32-09599 Research Fellowship
Departments of Surgical Oncology and Cancer Biology
University of Texas M. D. Anderson Cancer Center
Houston, Texas
2005-2006
General Surgery Residency
University of Texas- Houston
Houston, Texas
2006-2007
Chief Resident in General Surgery
University of Texas- Houston
Houston, Texas
2007-2009
Surgical Oncology Fellowship
Fox Chase Cancer Center
Philadelphia, Pennsylvania
Advanced Surgical Training:
2008
Video-Assisted Thoracic Surgery Course
Covidien Surgical Education
Norwalk, CT
Director: Thomas D’Amico M.D.
2008
Advanced Laparoscopic Colon Surgery Course
New York Presbyterian Hospital – Weill Medical College
New York, NY
Directors: Jeffrey Milsom M.D. and Sang Lee M.D.
Academic/ Clinical Appointments:
2003-2005
Clinical Specialist
Department of Cardiovascular and Thoracic Surgery
University of Texas M. D. Anderson Cancer Center
Houston, Texas
2004-2005
Clinical Specialist
Department of Critical Care
University of Texas M. D. Anderson Cancer Center
Houston, Texas
2007-present
Clinical Instructor
Department of Surgical Oncology
Fox Chase Cancer Center
Philadelphia, Pennsylvania
2007-present
Clinical Instructor
Department of General Surgery
Temple University Medical School
Philadelphia, Pennsylvania
Honors and Awards:
Dean’s List – Abilene Christian University
Dean’s List – University of North Texas Health Science Center
1997
Outstanding Student in Clinical Pharmacology
University of North Texas Health Science Center
1998
Outstanding Student in Public Health and Preventative Medicine
University of North Texas Health Science Center
1998-1999
Founder’s Guild Scholarship
University of North Texas Health Science Center
2005
American Society of Clinical Oncology Merit Award
2007
American College of Surgeons, South Texas Chapter
Surgical Jeopardy Champion
Professional Memberships and Committees:
American College of Surgeons, Associate
American Association for Cancer Research, Associate
American Society of Clinical Oncology, Associate
Society of Surgical Oncology, Associate
Society for Surgery of the Alimentary Tract, Member
American Medical Association
Texas Medical Association
Harris County Medical Society
Articles in Refereed Journals:
1. Lesslie, DP 3rd, Gallick GE. Src Family Kinases as Regulators of Angiogenesis: Therapeutic Implications. Current Cancer Therapy Reviews, 1(1): 45-51, 2005.
2. Trevino JG, Summy JM, Gray MJ, Nilsson MB, Lesslie DP 3rd, Baker CH, Gallick GE. Expression and Activity of Src Regulate Interleukin-8 Expression in Pancreatic Adenocarcinoma Cells: Implications for Angiogenesis. Cancer Research. 65(16): 1714-22, 2005.
3. Summy JM, Trevino JG, Lesslie DP 3rd, Baker CH, Shakespeare WC, Yang Y, Sundaramoorthi R, Metcalf CA 3rd, Keats JA, Sawyer TK, Gallick GE. AP23846, a Novel and Highly Potent Src Family Kinase Inhibitor, Reduces VEGF and IL-8 Expression in Human Solid Tumor Cell Lines and Abrogates Downstream Angiogenic Processes. Molecular Cancer Therapeutics. 4(12): 1900-11, 2005.
4. Trevino JG, Summy JM, Lesslie DP 3rd, Lee FY, Hong DS, Donato NJ, Baker CH, Gallick GE. Inhibition of Src Expression and Kinase Activity Inhibits Development of Metastases of Human Pancreatic Adenocarcinoma Cells in a Nude Mouse Model. American Journal of Pathology. 168(3): 962-72, 2006.
5. Lesslie, DP 3rd, Summy, JM, Parikh, NU, Fan F, Trevino JG, Sawyer TK, Metcalf CA 3rd, Shakespeare WC, Hicklin DJ, Ellis LM, Gallick GE. Vascular Endothelial Growth Factor Receptor-1 Mediates Migration of Human Colorectal Carcinoma Cells By Activation of Src Family Kinases. British Journal of Cancer. 94(11): 1710-17, 2006.
6. Trevino JG, Gray MJ, Summy JM, Nawrocki ST, Lesslie DP 3rd, Evans DB, Chiao PJ, McConkey DJ, Gallick GE.Src, STAT3, and NF-kB are Required for Constitutive IL-8 Expression in Human Pancreatic Adenocarcinoma Cells. Angiogenesis. 9(2): 101-10, 2006.
7. Bauer TW, Somcio RJ, Fan F, Liu W, Johnson M, Lesslie DP 3rd, Evans DB, Gallick GE, Ellis LM. Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells. Molecular Cancer Therapeutics. 5(7): 1676-82, 2006.
Articles Submitted/ In Preparation:
1. Kopetz S*, Lesslie, DP 3rd *, Dallas N, Parikh NU, Shah A, Summy JM, Lee FY, Hong DS, Donato NJ, Ellis LM, Gallick GE. Synergistic Activity of the Src Family Kinase Inhibitor Dasatinib and Oxaliplatin in Colon Cancer Cells is Mediated by Reactive Oxygen Species. Cancer Research. Review pending.
2. Lesslie, DP 3rd, Parikh, NU, Shah, A, Summy, JM, Trevino, JG, Lee, FY, Hong DS, Donato NJ, Gallick, GE. SRC Kinase Inhibition by Dasatinib (BMS-354825) Reduces Tumor Formation and Prevents Malignant Ascites in a Murine Model of Carcinomatosis. Manuscript in preparation.
Published Abstracts/ Presentations:
1. Lesslie, DP 3rd, Hicklin, DJ, Sawyer, TK, Shakespeare, WC, Ellis, LM, Gallick, GE. Vascular endothelial growth factor receptor-1 (VEGFR-1) signaling promotes colon cancer cell migration via a Src family kinase dependent mechanism. Proceedings of the 2005 Gastrointestinal Cancers Symposium, A274, 2005.
2. Lesslie, DP 3rd, Ellis, LM, Hicklin, DJ, Sawyer, TK, Shakespeare, WC, Gallick, GE. VEGFR-1 signaling in human colorectal carcinoma: Role for Src in VEGF-induced migration. Annals of Surgical Oncology, 12(2):8:S10, 2005.
3. Lesslie, DP 3rd, Langley, RR, Gallick, GE. Src regulates angiogenesis induced by human colorectal carcinoma cells. Proceedings of the American Association for Cancer Research 96th Annual Meeting, A2024, 2005.
4. Lesslie, DP 3rd, Hicklin, DJ, Ellis, LM, Gallick, GE. Src family kinases and VEGFR-1 are required for VEGF-induced migration in human colorectal carcinoma cells. Proceedings of the American Association for Cancer Research 96th Annual Meeting, A5542, 2005.
5. Trevino, JG, Summy, JM, Lesslie, DP 3rd, Lee, FY, Donato, NJ, Baker, CH Gallick, GE. Inhibition of Src Expression/Activity Delays Development of Metastases in Human Pancreatic Adenocarcinoma Cells, American College of Surgeons (ACS) 91st Annual Clinical Congress, Surgical Forum Program, 2005-157.
6. Lesslie, DP 3rd, Fan F, Trevino JG, Sawyer TK, Metcalf CA 3rd, Shakespeare WC, Hicklin, DJ, Ellis LM, Gallick GE. Vascular Endothelial Growth Factor Receptor-1 Mediates Migration of Human Colorectal Carcinoma Cells By Activation of Src Family Kinases. American College of Surgeons, South Texas Chapter. 2006.
7. Vercruysse, GA, Lesslie, DP 3rd. Delayed Cardiac Tamponade Following Blunt Thoracic Trauma. American College of Surgeons, South Texas Chapter. 2006.
8. Lesslie, DP 3rd, Shah, A, Summy, JM, Trevino, JG, Lee, FY, Hong DS, Donato NJ, Gallick, GE. Combined Activity of Oxaliplatin and Dasatinib (BMS-354825) in an Orthotopic Model of Metastatic Colorectal Cancer. Proceedings of the American Association for Cancer Research 97th Annual Meeting, A4745, 2006.
9. Summy JM, Trevino JG, Lesslie DP 3rd, Lee FY, Hong DS, Donato NJ, Baker CH, Gallick GE. Inhibition of Src Expression and Kinase Activity Inhibits Development of Metastases of Human Pancreatic Adenocarcinoma Cells in a Nude Mouse Model. Proceedings of the American Association for Cancer Research 97th Annual Meeting, A5103, 2006.
10. Lesslie, DP 3rd, Parikh, NU, Shah, A, Summy, JM, Trevino, JG, Lee, FY, Hong DS, Donato NJ, Gallick, GE. Dasatinib (BMS-354825), a Dual SRC/ ABL Tyrosine Kinase Inhibitor, Inhibits Tumor Formation and Prevents Malignant Ascites Formation in a Murine Model of Peritoneal Carcinomatosis. American College of Surgeons (ACS) 92nd Annual Clinical Congress, Surgical Forum Program, 2006.
11. “Enteral Nutrition in the Surgical Intensive Care Unit”, Grand Rounds Presentation, University of Texas Medical School at Houston. December 7, 2006.
12. “Targeted Therapy for Advanced Colorectal Cancer: Beyond VEGF and EGFR”, Department of Surgical Oncology Grand Rounds Presentation, Fox Chase Cancer Center. July 29, 2008.
